|Full Name||filamin A, alpha|
|Product Description||Rabbit Polyclonal antibody to Filamin A (filamin A, alpha)|
|Background||The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||ABP-280 antibody, ABPX antibody, CVD1 antibody, DKFZp434P031 antibody, FLN antibody, FLN-A antibody, FLN1 antibody, FMD antibody, MNS antibody, NHBP antibody, OPD antibody, OPD1 antibody, OPD2 antibody, XLVD antibody, XMVD antibody, FLNA antibody, filamin-1 antibody, actin binding protein 280 antibody, alpha-filamin antibody, endothelial actin-binding protein antibody, filamin-A antibody, non-muscle filamin antibody, "filamin A, alpha antibody"|
|Cellular Localization||Cytoplasm , cell cortex , cytoskeleton |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human Filamin A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (96%), Rabbit (98%), Bovine (98%)|