|Full Name||frizzled homolog 2 (Drosophila)|
|Product Description||Goat polyclonal antibody to Frizzled 2|
|Background||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
|Synonyms||frizzled homolog 2 (Drosophila), FZD2, Frizzled 2, frizzled homolog2 (Drosophila), frizzled2, Fz2, fz-2, fzE2, hFz2, fz 2|
|Specificity||This antibody is specific for Frizzled 2.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.