|Full Name||frizzled homolog 7 (Drosophila)|
|Product Description||Goat polyclonal antibody to Frizzled 7|
|Background||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
|Synonyms||rizzled7, Frizzled 7, frizzled homolog 7 (Drosophila), Frizzled7, frizzled homolog7 (Drosophila), rizzled 7, Frizzled, drosophila, homolog of, 7, FzE3, FZD7|
|Specificity||This antibody is specific for Frizzled 7.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.