Fumarate hydratase antibody [N2C2], Internal
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||55 kDa (note)
|Positive Controls||293T , A431 , mosue liver , rat liver|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||fumarate hydratase|
|Product Description||Rabbit Polyclonal antibody to Fumarate hydratase (fumarate hydratase)|
|Background||The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq]|
|Synonyms||HLRCC antibody, LRCC antibody, MCL antibody, MCUL1 antibody, FH antibody, fumarase antibody, fumarate hydratase, mitochondrial antibody, fumarate hydratase antibody|
|Cellular Localization||Mitochondrion , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Fumarate hydratase. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Pig, Chicken, Sheep, Chimpanzee, Bovine|
|Predict Reactivity Note||Zebrafish (86%), Pig (97%), Chicken (89%), Sheep (97%), Chimpanzee (99%), Bovine (96%)|