|Full Name||guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1|
|Product Description||Rabbit Polyclonal antibody to G protein alpha Inhibitor 1 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1)|
|Background||Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 139320) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1; MIM 139311); and transducin-1 (GNAT1; MIM 139330) and transducin-2 (GNAT2; MIM 139340), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 3092218]; Bray et al., 1987 [PubMed 3110783]). Suki et al. (1987) [PubMed 2440724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein; see, e.g, GNAI2 (MIM 139360), GNAI3 (MIM 139370), and GNAIH (MIM 139180).[supplied by OMIM]|
|Synonyms||Gi antibody, GNAI1 antibody, Gi1 protein alpha subunit antibody, adenylate cyclase-inhibiting G alpha protein antibody, guanine nucleotide-binding protein G(i) subunit alpha-1 antibody, "guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human G protein alpha Inhibitor 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Pig, Chicken, Bovine, Guinea pig|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Zebrafish (97%), Xenopus laevis (97%), Pig (98%), Chicken (97%), Bovine (98%), Guinea pig (97%)|