|Full Name||glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)|
|Product Description||Rabbit Polyclonal antibody to GAD65 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa))|
|Background||This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq]|
|Synonyms||GAD65 antibody, MGC161605 antibody, MGC161607 antibody, GAD2 antibody, 65 kDa glutamic acid decarboxylase antibody, glutamate decarboxylase 65 kDa isoform antibody, GAD-65 antibody, glutamate decarboxylase 2 antibody, Glutamate decarboxylase-2 (pancreas) antibody, glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) antibody|
|Cellular Localization||Cytoplasm , cytosol , Cytoplasmic vesicle , Cell junction , synapse , presynaptic cell membrane , Golgi apparatus membrane |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human GAD65. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Dog, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Zebrafish (86%), Dog (96%), Pig (95%), Rhesus Monkey (100%), Bovine (93%)|