|Full Name||DNA-damage-inducible transcript 3|
|Product Description||Rabbit Polyclonal antibody to GADD153 (DNA-damage-inducible transcript 3)|
|Background||This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq]|
|Synonyms||CEBPZ antibody, CHOP antibody, CHOP-10 antibody, CHOP10 antibody, GADD153 antibody, MGC4154 antibody, DDIT3 antibody, DNA damage-inducible transcript 3 protein antibody, growth arrest and DNA damage-inducible protein GADD153 antibody, c/EBP-homologous protein 10 antibody, CCAAT/enhancer-binding protein homologous protein antibody, C/EBP zeta antibody, DDIT-3 antibody, DNA-damage-inducible transcript 3 antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GADD153. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (100%), Rhesus Monkey (100%), Bovine (100%)|