|Product Description||Rabbit polyclonal antibody to GALE (UDP-galactose-4-epimerase)|
|Background||This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq]|
|Synonyms||FLJ95174 antibody, FLJ97302 antibody, SDR1E1 antibody, GALE antibody, galactowaldenase antibody, UDP galactose-4'-epimerase antibody, "galactose-4-epimerase, UDP- antibody", "short chain dehydrogenase/reductase family 1E, member 1 antibody", UDP-galactose 4-epimerase antibody, UDP-glucose 4-epimerase antibody, UDP-galactose-4-epimerase antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GALE. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Zebrafish (82%), Rhesus Monkey (98%), Bovine (97%)|