GBA antibody [C1C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||60 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||glucosidase, beta, acid|
|Product Description||Rabbit Polyclonal antibody to GBA (glucosidase, beta, acid)|
|Background||This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]|
|Synonyms||GBA1 antibody, GCB antibody, GLUC antibody, GBA antibody, imiglucerase antibody, lysosomal glucocerebrosidase antibody, glucosylceramidase antibody, acid beta-glucosidase antibody, beta-glucocerebrosidase antibody, D-glucosyl-N-acylsphingosine glucohydrolase antibody, alglucerase antibody, "glucosidase, beta, acid antibody"|
|Cellular Localization||Lysosome membrane; Peripheral membrane protein; Lumenal side |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human GBA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (91%), Pig (92%), Chimpanzee (100%), Bovine (92%)|