|Full Name||glucosidase, beta, acid|
|Product Description||Rabbit Polyclonal antibody to GBA (glucosidase, beta, acid)|
|Background||This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]|
|Synonyms||GBA1 antibody, GCB antibody, GLUC antibody, GBA antibody, imiglucerase antibody, lysosomal glucocerebrosidase antibody, glucosylceramidase antibody, acid beta-glucosidase antibody, beta-glucocerebrosidase antibody, D-glucosyl-N-acylsphingosine glucohydrolase antibody, alglucerase antibody, glucosidase, beta, acid antibody|
|Cellular Localization||Lysosome membrane; Peripheral membrane protein; Lumenal side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GBA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (84%), Rat (85%), Pig (90%), Chimpanzee (100%), Bovine (89%)|