|Full Name||glutamate-cysteine ligase, catalytic subunit|
|Product Description||Rabbit polyclonal antibody to GCLC (glutamate-cysteine ligase, catalytic subunit)|
|Background||Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. [provided by RefSeq]|
|Synonyms||GCL antibody, GCS antibody, GLCL antibody, GLCLC antibody, GCLC antibody, glutamate--cysteine ligase catalytic subunit antibody, gamma-glutamylcysteine synthetase antibody, gamma-ECS antibody, GCS heavy chain antibody, "glutamate-cysteine ligase, catalytic subunit antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GCLC. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (92%), Rat (91%), Rhesus Monkey (99%), Bovine (94%)|