|Full Name||glial cell derived neurotrophic factor|
|Product Description||Rabbit Polyclonal antibody to GDNF (glial cell derived neurotrophic factor)|
|Background||This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq]|
|Synonyms||ATF1 antibody, ATF2 antibody, HFB1-GDNF antibody, HSCR3 antibody, GDNF antibody, glial cell line-derived neurotrophic factor antibody, astrocyte-derived trophic factor antibody, ATF antibody, glial cell derived neurotrophic factor antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GDNF. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (93%), Rat (93%), Bovine (91%)|