| Full Name | growth factor independent 1B transcription repressor |
| Product Description | Rabbit Polyclonal antibody to GFI1b |
| Background | Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. |
| Synonyms | GFI1B, potential regulator of CDKN1A translocated in CML, growth factor independent 1B (potential regulator of CDKN1A, translocated in CML), growth factor independent protein 1B, zinc finger protein Gfi-1b, growth factor independent 1B transcription repressor |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | GFI1b |
| Immunogen | Peptide sequence around aa.322~326(H-R-E-S-Q) derived from Human GFI1b. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat |