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1 .GTX50844 GFI1b antibody 

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GFI1b antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsWB
  • Species reactivityHuman, Mouse, Rat
Cat No: GTX50844
Package Price Qty
100 μlUSD 319.00
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  • Anti-GFI1b antibody used in Western Blot (WB). GTX50844
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  • Datasheet
  • Application Information: GFI1b antibody

Catalog Number GTX50844
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Product Name GFI1b antibody
See all GFI1b products
ApplicationsWB
Application NoteSuggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Predicted Target Size38 (note)
Form SuppliedLiquid
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
PurificationAntibodies were purified by affinity-chromatography using epitope-specific peptide.

  • Specifications: GFI1b antibody

Full Namegrowth factor independent 1B transcription repressor
BackgroundEssential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
SynonymsGFI1B, potential regulator of CDKN1A translocated in CML, growth factor independent 1B (potential regulator of CDKN1A, translocated in CML), growth factor independent protein 1B, zinc finger protein Gfi-1b, growth factor independent 1B transcription repressor
HostRabbit
ClonalityPolyclonal
ImmunogenPeptide sequence around aa.322~326(H-R-E-S-Q) derived from Human GFI1b.
Antigen SpeciesHuman
Species ReactivityHuman, Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: GFI1b antibody

Storage Buffersaline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
GFI1b antibody validated data
  • Anti-GFI1b antibody used in Western Blot (WB). GTX50844
    • GTX50844 WB Image
      Western blot analysis of extracts from Raji cells using GFI1b Antibody GTX50844.
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  • Anti-GFI1b antibody used in Western Blot (WB). GTX50844
    • GTX50844 WB Image
      Western blot analysis of extracts from Raji cells using GFI1b Antibody GTX50844.
      Top
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