Full Name | tumor necrosis factor receptor superfamily, member 18 |
Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
Synonyms | AITR Antibody , GITR Antibody , tumor necrosis factor receptor superfamily, member 18 Antibody , CD357 Antibody , GITR-D Antibody |
Specificity | This antibody was selected for its ability to detect human GITR |
Host | Mouse |
Clonality | Monoclonal |
Clone Name | 7R12 |
Isotype | IgG1 |
Immunogen | Human recombinant TNFRSF18 EC domain |
Antigen Species | Human |
Species Reactivity | Human |
Conjugation | Unconjugated |