| Full Name | tumor necrosis factor receptor superfamily, member 18 |
| Product Description | Mouse monoclonal antibody [7R12] to GITR |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| Synonyms | AITR Antibody , GITR Antibody , tumor necrosis factor receptor superfamily, member 18 Antibody , CD357 Antibody , GITR-D Antibody |
| Specificity | This antibody was selected for its ability to detect human GITR |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 7R12 |
| Target | TNFRSF18 |
| Isotype | IgG1 |
| Immunogen | Human recombinant TNFRSF18 EC domain |
| Antigen Species | Human |
| Species Reactivity | Human |