|Full Name||GLE1 RNA export mediator homolog (yeast)|
|Product Description||Rabbit Polyclonal antibody to GLE1 (GLE1 RNA export mediator homolog (yeast))|
|Background||This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||GLE1L antibody, LCCS antibody, LCCS1 antibody, hGLE1 antibody, GLE1 antibody, "GLE1-like, RNA export mediator antibody", GLE1-like protein antibody, nucleoporin GLE1 antibody, GLE1 RNA export mediator homolog (yeast) antibody|
|Cellular Localization||Nucleus , Cytoplasm , Isoform 1: Cytoplasm , nuclear pore complex |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human GLE1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (93%), Rhesus Monkey (99%), Bovine (96%)|