|Full Name||G protein pathway suppressor 2|
|Product Description||Rabbit Polyclonal antibody to GPS2 (G protein pathway suppressor 2)|
|Background||This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq]|
|Synonyms||AMF-1 antibody, MGC104294 antibody, MGC119287 antibody, MGC119288 antibody, MGC119289 antibody, GPS2 antibody, GPS-2 antibody, G protein pathway suppressor 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GPS2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Bovine (98%)|