|Full Name||Rho GTPase activating protein 26|
|Product Description||Rabbit Polyclonal antibody to GRAF (rho GTPase-activating protein 26)|
|Background||Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||FLJ42530 antibody, GRAF antibody, KIAA0621 antibody, OPHN1L antibody, OPHN1L1 antibody, ARHGAP26 antibody, GTPase regulator associated with focal adhesion kinase pp125(FAK) antibody, oligophrenin-1-like protein antibody, rho GTPase-activating protein 26 antibody, Rho GTPase activating protein 26 antibody|
|Cellular Localization||Cell junction , focal adhesion (By similarity) , Cytoplasm , cytoskeleton (By similarity) |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GRAF. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chicken (100%), Bovine (100%)|