Full Name | growth factor receptor-bound protein 10 |
Background | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] |
Synonyms | Grb-10 Antibody , GRB-IR Antibody , IRBP Antibody , RSS Antibody , MEG1 Antibody , GRB10 Antibody , growth factor receptor-bound protein 10 Antibody |
Specificity | Recognizes endogenous levels of GRB10 (pY67) protein. |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GRB10. The exact sequence is proprietary. |
Antigen Species | Human |
Species Reactivity | Human, Mouse, Rat |
Conjugation | Unconjugated |