GRK2 antibody [C2C3], C-term
|Applications||FACS, ICC/IF, IHC-P, IP, WB|
Not tested in other applications.
| Flow cytometry/FACS||Assay-dependent dilution
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||80 kDa (note)
|Positive Controls||293T , A431 , HeLaS3 , HepG2 , Molt-4 , Raji , NIH-3T3 , Jurkat , NCI-H929|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||adrenergic, beta, receptor kinase 1|
|Product Description||Rabbit Polyclonal antibody to GRK2 (adrenergic, beta, receptor kinase 1)|
|Background||The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]|
|Synonyms||BARK1 antibody, BETA-ARK1 antibody, FLJ16718 antibody, GRK2 antibody, ADRBK1 antibody, G-protein coupled receptor kinase 2 antibody, beta-ARK-1 antibody, beta-adrenergic receptor kinase 1 antibody, "adrenergic, beta, receptor kinase 1 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human GRK2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|
|Predict Reactivity Note||Rat (98%), Pig (98%), Bovine (98%)|