|Full Name||glutathione S-transferase alpha 2|
|Product Description||Rabbit Polyclonal antibody to GSTA2 (glutathione S-transferase alpha 2)|
|Background||Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq]|
|Synonyms||GST2 antibody, GSTA2-2 antibody, GTA2 antibody, GTH2 antibody, MGC10525 antibody, GSTA2 antibody, glutathione S-aralkyltransferase A2 antibody, glutathione S-aryltransferase A2 antibody, GST HA subunit 2 antibody, glutathione S-alkyltransferase A2 antibody, liver GST2 antibody, S-(hydroxyalkyl)glutathione lyase A2 antibody, GST class-alpha member 2 antibody, glutathione S-transferase A2 antibody, GST-gamma antibody, glutathione S-transferase alpha 2 antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GSTA2. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Rhesus Monkey|
|Predict Reactivity Note||Pig (82%), Rhesus Monkey (92%)|