|Full Name||glutathione S-transferase mu 5|
|Product Description||Rabbit Polyclonal antibody to GSTM5 (glutathione S-transferase mu 5)|
|Background||Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq]|
|Synonyms||GSTM5-5 antibody, GTM5 antibody, GSTM5 antibody, S-(hydroxyalkyl)glutathione lyase M5 antibody, glutathione S-aryltransferase M5 antibody, GST class-mu 5 antibody, glutathione S-alkyltransferase M5 antibody, glutathione S-aralkyltransferase M5 antibody, glutathione S-transferase Mu 5 antibody, glutathione S-transferase M5 antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GSTM5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%)|