Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||74 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , NIH-3T3 , JC , BCL-1|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||GTP binding protein 4|
|Product Description||Rabbit Polyclonal antibody to GTPBP4 (GTP binding protein 4)|
|Background||GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq]|
|Synonyms||CRFG antibody, FLJ10686 antibody, FLJ10690 antibody, FLJ39774 antibody, NGB antibody, NOG1 antibody, GTPBP4 antibody, GTP-binding protein NGB antibody, G protein-binding protein CRFG antibody, nucleolar GTP-binding protein 1 antibody, chronic renal failure gene protein antibody, GTP binding protein 4 antibody|
|Cellular Localization||Nucleus , nucleolus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human GTPBP4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (88%), Bovine (87%)|