Gephyrin antibody [N2C1], Internal
|Applications||IHC-Fr, IHC-P, IP, WB|
Not tested in other applications.
|IHC (Frozen sections)||1:100-1:1000*
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||80 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , NIH-3T3 , JC , PC-12|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Product Description||Rabbit Polyclonal antibody to Gephyrin (gephyrin)|
|Background||This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq]|
|Synonyms||GEPH antibody, GPH antibody, GPHRYN antibody, KIAA1385 antibody, GPHN antibody, gephyrin antibody|
|Cellular Localization||Cell junction , synapse (By similarity) , synapse , postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) , Cytoplasm , cytoskeleton (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Gephyrin. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Chicken, Rhesus Monkey|
|Predict Reactivity Note||Xenopus laevis (99%), Pig (100%), Chicken (100%), Rhesus Monkey (100%)|