|Full Name||nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)|
|Product Description||Rabbit Polyclonal antibody to Glucocorticoid receptor (phospho Ser211)|
|Background||This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]|
|Synonyms||GCR Antibody , GRL Antibody , GR Antibody , NR3C1 Antibody , nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Antibody , GCCR Antibody , GCRST Antibody|
|Specificity||Recognizes endogenous levels of Glucocorticoid Receptor (pS211) protein.|
|Immunogen||KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Glucocorticoid Receptor (pS211). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (100%)|