|Full Name||growth hormone receptor|
|Product Description||Rabbit Polyclonal antibody to Growth hormone Receptor (growth hormone receptor)|
|Background||This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein.|
|Synonyms||GHBP antibody, GHR antibody, somatotropin receptor antibody, serum binding protein antibody, growth hormone receptor antibody, growth hormone binding protein antibody, GH receptor antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein , Isoform 2: Cell membrane; Single-pass type I membrane protein , Growth hormone-binding protein: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Growth hormone Receptor. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Sheep, Rhesus Monkey|
|Predict Reactivity Note||Pig (81%), Sheep (80%), Rhesus Monkey (95%)|