|Full Name||3-hydroxyanthranilate 3,4-dioxygenase|
|Product Description||Rabbit Polyclonal antibody to HAAO (3-hydroxyanthranilate 3,4-dioxygenase)|
|Background||3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq]|
|Synonyms||3-HAO antibody, HAO antibody, HAAO antibody, HAD antibody, "3-hydroxyanthranilate 3,4-dioxygenase antibody", 3-hydroxyanthranilate oxygenase antibody, 3-hydroxyanthranilic acid dioxygenase antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HAAO. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|
|Predict Reactivity Note||Rat (90%), Pig (88%), Bovine (89%)|