|Full Name||histidyl-tRNA synthetase|
|Product Description||Rabbit Polyclonal antibody to HARS (histidyl-tRNA synthetase)|
|Background||Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. [provided by RefSeq]|
|Synonyms||FLJ20491 antibody, HRS antibody, HARS antibody, "histidine tRNA ligase 1, cytoplasmic antibody", histidine-tRNA ligase antibody, HisRS antibody, "histidyl-tRNA synthetase, cytoplasmic antibody", histidine--tRNA ligase antibody, histidine translase antibody, histidyl-tRNA synthetase antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HARS. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Zebrafish (84%), Chicken (89%), Chimpanzee (99%), Bovine (96%)|