|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||32 kDa (note)
|Positive Controls||Molt-4 , Raji , 293T , A431 , HeLa , HepG2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||HCLS1 associated protein X-1|
|Product Description||Rabbit Polyclonal antibody to HAX1 (HCLS1 associated protein X-1)|
|Background||The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||FLJ17042 antibody, FLJ18492 antibody, FLJ93803 antibody, HCLSBP1 antibody, HS1BP1 antibody, SCN3 antibody, HAX1 antibody, HAX-1 antibody, HCLS1-associated protein X-1 antibody, HSP1BP-1 antibody, HS1-binding protein 1 antibody, HS1 binding protein antibody, HS1-associating protein X-1 antibody, HCLS1 (and PKD2) associated protein antibody, HCLS1 associated protein X-1 antibody|
|Cellular Localization||Mitochondrion , Endoplasmic reticulum , Nucleus membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HAX1. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rhesus Monkey (97%), Bovine (84%)|