|Full Name||homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1|
|Product Description||Rabbit Polyclonal antibody to HERPUD1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1)|
|Background||The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq]|
|Synonyms||HERP antibody, KIAA0025 antibody, Mif1 antibody, SUP antibody, HERPUD1 antibody, homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein antibody, homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein antibody, methyl methanesulfonate (MMF)-inducible fragment protein 1 antibody, MMS-inducible antibody, "homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 antibody"|
|Cellular Localization||Endoplasmic reticulum membrane; Single-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HERPUD1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (83%), Bovine (87%)|