|Full Name||exoribonuclease 1|
|Product Description||Rabbit Polyclonal antibody to HEXO (exoribonuclease 1)|
|Background||RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. |
|Synonyms||exoribonuclease 1 Antibody , THEX1 Antibody , 3'HEXO Antibody , ERI1 Antibody|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus (By similarity) , Nucleus , nucleolus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HEXO. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Bovine|
|Predict Reactivity Note||Mouse (89%), Rat (91%), Chicken (83%), Bovine (96%)|