|Full Name||huntingtin interacting protein 1|
|Product Description||Rabbit Polyclonal antibody to HIP1 (huntingtin interacting protein 1)|
|Background||The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined. [provided by RefSeq]|
|Synonyms||HIP-1 antibody , HIP1 antibody , HIP1 antibody , ILWEQ antibody , huntingtin interacting protein 1 antibody|
|Cellular Localization||Cytoplasm , Nucleus , Endomembrane system , Cytoplasmic vesicle , clathrin-coated vesicle membrane|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HIP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (88%), Rat (88%), Bovine (85%)|