|Product Description||Rabbit Polyclonal antibody to HIP55 (drebrin-like)|
|Background||Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. |
|Synonyms||ABP1 antibody, HIP-55 antibody, SH3P7 antibody, DBNL antibody, SH3 domain-containing protein 7 antibody, drebrin-like protein antibody, cervical SH3P7 antibody, cervical mucin-associated protein antibody, src homology 3 domain-containing protein HIP-55 antibody, drebrin-F antibody, HPK1-interacting protein of 55 kDa antibody, drebrin-like antibody|
|Cellular Localization||Cytoplasm , cytoskeleton , Cell projection , lamellipodium |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human HIP55. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (92%), Rat (92%), Bovine (84%)|