HIPPI antibody [C1C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||49 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||intraflagellar transport 57 homolog (Chlamydomonas)|
|Product Description||Rabbit Polyclonal antibody to HIPPI (intraflagellar transport 57 homolog (Chlamydomonas))|
|Background||Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.|
|Synonyms||ESRRBL1 antibody, FLJ10147 antibody, HIPPI antibody, MHS4R2 antibody, IFT57 antibody, estrogen-related receptor beta-like protein 1 antibody, HIP1 protein interactor antibody, intraflagellar transport protein 57 homolog antibody, HIP1-interacting protein antibody, dermal papilla-derived protein 8 antibody, estrogen-related receptor beta like 1 antibody, huntingtin interacting protein-1 interacting protein antibody, intraflagellar transport 57 homolog (Chlamydomonas) antibody|
|Cellular Localization||Cell projection , cilium basal body (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HIPPI. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (90%), Rat (90%), Xenopus laevis (80%), Rhesus Monkey (99%), Bovine (91%)|