|Full Name||intraflagellar transport 57 homolog (Chlamydomonas)|
|Product Description||Goat polyclonal antibody to HIPPI|
|Background||Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
|Synonyms||estrogenrelated receptor beta like 1, ESRRBL1, MHS4R2, IFT57, intraflagellar transport 57 homolog (Chlamydomonas), huntingtin interacting protein1 interacting protein, HIP1 protein interactor, estrogenrelated receptor beta like1, estrogen-related receptor beta like 1, hunt, intraflagellar transport57 homolog (Chlamydomonas), FLJ10147, HIPPI|
|Cellular Localization||Concentrates within the inner segment of cilia. |
|Specificity||This antibody is specific for HIPPI.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.