|Full Name||major histocompatibility complex, class I, C|
|Product Description||Rabbit polyclonal antibody to HLA-C (major histocompatibility complex, class I, C)|
|Background||HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq]|
|Synonyms||D6S204 antibody, FLJ27082 antibody, HLA-Cw antibody, HLA-JY3 antibody, HLC-C antibody, PSORS1 antibody, HLA-C antibody, "HLA class I histocompatibility antigen, Cw-1 alpha chain antibody", MHC class I antigen heavy chain HLA-C antibody, human leukocyte antigen-C alpha chain antibody, major histocompatibility antigen HLA-C antibody, "HLA class I histocompatibility antigen, C alpha chain antibody", "major histocompatibility complex, class I, C antibody"|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HLA-C. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%)|