|Product Description||PE-conjugated Mouse Monoclonal antibody [MEM-123] to HLA-Class I|
|Background||HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules. Entrez Gene (HLA-A; human): 6p21.3Entrez Gene (HLA-B; human): 6p21.3Entrez Gene (HLA-C; human): 6p21.3|
|Synonyms||HLA Class I, HLAClass I|
|Specificity||The antibody MEM-123 reacts with all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.|
The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks the antibody MEM-G/9.
|Immunogen||COS-7 African green monkey kidney cells|
|Antigen Species||African green monkey|
|Species Reactivity||Human, Primate, Bovine|