|Full Name||major histocompatibility complex, class II, DM alpha|
|Product Description||Rabbit Polyclonal antibody to HLA-DMA (major histocompatibility complex, class II, DM alpha)|
|Background||HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq]|
|Synonyms||D6S222E antibody, DMA antibody, HLADM antibody, RING6 antibody, HLA-DMA antibody, MHC class II antigen DMA antibody, "class II histocompatibility antigen, M alpha chain antibody", really interesting new gene 6 protein antibody, "HLA class II histocompatibility antigen, DM alpha chain antibody", "major histocompatibility complex, class II, DM alpha antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HLA-DMA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (83%)|