| Background | HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq] |
| Synonyms | DPB1 antibody, HLA-DP1B antibody, HLA-DPB antibody, HLA-DPB1 antibody, MHC class II HLA-DRB1 antibody, MHC HLA DPB1 antibody, "HLA class II histocompatibility antigen, DP(W4) beta chain antibody", "HLA class II histocompatibility antigen, DP beta 1 chain antibody", major histocompatibility complex class II HLA DPB1 protein antibody, MHC class II HLA-DP-beta antibody, MHC class II HLA-DP-beta-1 antibody, beta1 domain MHC class II HLA DPB antibody, MHC class II antigen DPB1 antibody, MHC class II antigen DP beta 1 chain antibody, MHC class II antigen DPbeta1 antibody, MHC class II antigen beta chain antibody, HLA DP14-beta chain antibody, "HLA-DP histocompatibility type, beta-1 subunit antibody", "major histocompatibility complex, class II, DP beta 1 antibody" |