|Full Name||major histocompatibility complex, class II, DR beta 1|
|Product Description||Rabbit polyclonal antibody to HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)|
|Background||HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]|
|Synonyms||DRB1 antibody, DRw10 antibody, FLJ75017 antibody, FLJ76359 antibody, HLA-DR1B antibody, HLA-DRB antibody, HLA-DRB1* antibody, SS1 antibody, HLA-DRB1 antibody, lymphocyte antigen DRB1 antibody, human leucocyte antigen DRB1 antibody, MHC class II antigen antibody, "major histocompatibility complex, class II, DR beta 1 antibody", "HLA class II histocompatibility antigen, DR-1 beta chain antibody", DW2.2/DR2.2 antibody, MHC class II HLA-DRw10-beta antibody, MHC class II HLA-DR-beta cell surface glycoprotein antibody, MHC class II HLA-DR beta 1 chain antibody|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HLA-DR. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Dog (86%)|