|Full Name||major histocompatibility complex, class II, DR alpha|
|Product Description||Rabbit polyclonal antibody to HLA-DRA (major histocompatibility complex, class II, DR alpha)|
|Background||HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq]|
|Synonyms||FLJ51114 antibody, HLA-DRA1 antibody, MLRW antibody, HLA-DRA antibody, MHC class II antigen DRA antibody, MHC cell surface glycoprotein antibody, histocompatibility antigen HLA-DR alpha antibody, "HLA class II histocompatibility antigen, DR alpha chain antibody", "major histocompatibility complex, class II, DR alpha antibody"|
|Cellular Localization||Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HLA-DRA. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (82%), Dog (87%)|