|Full Name||3-hydroxy-3-methylglutaryl-CoA reductase|
|Product Description||Rabbit polyclonal antibody to HMG-CoA reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase)|
|Background||HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||LDLCQ3 antibody, HMGCR antibody, hydroxymethylglutaryl-CoA reductase antibody, HMG-CoA reductase antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody, 3-hydroxy-3-methylglutaryl-CoA reductase antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein , Peroxisome membrane; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human HMGCR. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Human (100%), Rat (93%), Xenopus laevis (85%), Pig (97%), Chicken (89%), Bovine (98%)|