|Full Name||hydroxysteroid (11-beta) dehydrogenase 2|
|Product Description||Rabbit polyclonal antibody to HSD11B2 (hydroxysteroid (11-beta) dehydrogenase 2)|
|Background||There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq]|
|Synonyms||AME antibody, AME1 antibody, HSD11K antibody, HSD2 antibody, SDR9C3 antibody, HSD11B2 antibody, 11-beta-hydroxysteroid dehydrogenase type II antibody, 11-beta-HSD2 antibody, 11-beta-hydroxysteroid dehydrogenase type 2 antibody, 11-beta-HSD antibody, 11-DH2 antibody, NAD-dependent 11-beta-hydroxysteroid dehydrogenase antibody, #NAME?, corticosteroid 11-beta-dehydrogenase isozyme 2 antibody, short chain dehydrogenase/reductase family 9C member 3 antibody, hydroxysteroid (11-beta) dehydrogenase 2 antibody|
|Cellular Localization||Microsome , Endoplasmic reticulum |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HSD11B2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Pig, Rabbit, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (83%), Rat (85%), Pig (81%), Rabbit (86%), Bovine (81%)|