|Full Name||BRISC and BRCA1 A complex member 1|
|Product Description||Rabbit Polyclonal antibody to HSPC142 (BRISC and BRCA1 A complex member 1)|
|Background||Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component. |
|Synonyms||C19orf62 antibody, FLJ20571 antibody, MERIT40 antibody, NBA1 antibody, BABAM1 antibody, new component of the BRCA1-A complex antibody, BRISC and BRCA1-A complex member 1 antibody, new component of the BRCAA1 A complex antibody, BRCA1-A complex subunit MERIT40 antibody, mediator of Rap80 interactions and targeting 40 kDa antibody, new component of the BRCA1 A complex antibody, mediator of RAP80 interactions and targeting subunit of 40 kDa antibody, BRISC and BRCA1 A complex member 1 antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human HSPC142. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (80%), Rhesus Monkey (98%), Bovine (95%)|