|Full Name||hyaluronoglucosaminidase 2|
|Product Description||Rabbit Polyclonal antibody to HYAL2 (hyaluronoglucosaminidase 2)|
|Background||This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. Varying functions have been described for this protein. It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI-anchored cell surface protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR. [provided by RefSeq]|
|Synonyms||LUCA2 antibody, HYAL2 antibody, hyaluronidase 2 antibody, lung carcinoma protein 2 antibody, PH-20 homolog antibody, PH20 homolog antibody, hyaluronidase-2 antibody, hyaluronoglucosaminidase-2 antibody, hyal-2 antibody, lysosomal hyaluronidase antibody, hyaluronoglucosaminidase 2 antibody|
|Cellular Localization||Cell membrane; Lipid-anchor , GPI-anchor |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HYAL2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (88%), Rat (87%), Pig (93%), Sheep (91%), Rhesus Monkey (100%), Bovine (91%)|