|Full Name||hairless homolog (mouse)|
|Product Description||Rabbit Polyclonal antibody to Hairless (hairless homolog (mouse))|
|Background||This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||ALUNC antibody, AU antibody, FLJ98880 antibody, HSA277165 antibody, MUHH antibody, MUHH1 antibody, HR antibody, protein hairless antibody, hairless homolog (mouse) antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Hairless. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rhesus Monkey|
|Predict Reactivity Note||Human (100%), Rhesus Monkey (89%)|