|Product Description||Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)|
|Background||This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||BP antibody, HP2ALPHA2 antibody, HPA1S antibody, MGC111141 antibody, HP antibody, haptoglobin antibody, "haptoglobin, alpha polypeptide antibody", "haptoglobin, beta polypeptide antibody", binding peptide antibody, haptoglobin alpha(2FS)-beta antibody, haptoglobin alpha(1S)-beta antibody|
|Cellular Localization||Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Haptoglobin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Cat, Pig, Rabbit, Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Mouse (81%), Rat (80%), Cat (83%), Pig (81%), Rabbit (86%), Rhesus Monkey (94%), Chimpanzee (98%)|