|Product Description||Rabbit polyclonal antibody to Heparanase 1 (heparanase)|
|Background||Heparan sulfate proteoglycans (HSPGs) are major components of the basement membrane and extracellular matrix. Heparanases, like HSPE, are endoglycosidases that cleave the heparan sulfate side chain of HSPGs to permit the remodeling of the extracellular matrix for cell movement or the release of bioactive molecules from the extracellular matrix or cell surface (summary by McKenzie et al., 2000 [PubMed 11027606]).[supplied by OMIM]|
|Synonyms||HPA antibody, HPA1 antibody, HPR1 antibody, HPSE1 antibody, HSE1 antibody, HPSE antibody, endo-glucoronidase antibody, heparanase-1 antibody, heparanase antibody|
|Cellular Localization||Lysosome membrane; Peripheral membrane protein , Secreted |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Heparanase 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%)|