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1 .GTX22429 Her2 / ErbB2 peptide

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Her2 / ErbB2 peptide


  • ApplicationsBlocking
  • Species reactivityHuman
Cat No: GTX22429
Package Price Qty
500 μlUSD 179.00
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  • Datasheet
  • Application Information: Her2 / ErbB2 peptide

Catalog Number GTX22429
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Product Name Her2 / ErbB2 peptide
See all ErbB2 products
Full Namev-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
SynonymsCD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, HER 2, HER 2/neu, HER2/neu
BackgroundErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1&2 and JAK/STAT signaling pathways, respectively.
SpeciesHuman
ApplicationsBlocking
Application NoteOptimal dilutions should be determined by the user.
Concentration0.2 mg/ml (Please refer to the vial label for the specific concentration)
Storage BufferPreservative: 0.1% Sodium Azide; Constituents: PBS, BSA
Storage InstructionStore this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Apoptosis > Metastasis and Invasion > Invasion
  • Cancer > Apoptosis > Metastasis and Invasion > Metastasis > Lymphatic
  • Cancer > Tumor biomarkers
  • Cancer > Type of cancer > Breast > Ductal
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Her2 / ErbB2 peptide validated data
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