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Catalog Number
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GTX22429
(
0
)
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Product Name
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Her2 / ErbB2 peptide
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| Full Name | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
| Synonyms | CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, HER 2, HER 2/neu, HER2/neu |
| Product Description | ErbB2 (C-term) peptide (human) |
| Background | ErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1&2 and JAK/STAT signaling pathways, respectively. |
| Target | ErbB2 |
| Species | Human |
| Applications | Blocking |
| Application Note | Optimal dilutions should be determined by the user. |
| Concentration | 0.2
mg/ml
(Please refer to the vial label for the specific concentration) |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: PBS, BSA |
| Storage Instruction | Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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