|Full Name||v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)|
|Product Description||Rabbit Polyclonal antibody to ERBB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian))|
|Background||This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]|
|Synonyms||HER4 antibody, MGC138404 antibody, p180erbB4 antibody, ERBB4 antibody, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 antibody, tyrosine kinase-type cell surface receptor HER4 antibody, proto-oncogene-like protein c-ErbB-4 antibody, receptor tyrosine-protein kinase erbB-4 antibody, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human ERBB4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (97%), Chicken (88%)|