Hexokinase 1 antibody
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||102 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||hexokinase 1|
|Product Description||Rabbit Polyclonal antibody to HXK I (hexokinase 1)|
|Background||Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq]|
|Synonyms||HK1-ta antibody, HK1-tb antibody, HK1-tc antibody, HKI antibody, HXK1 antibody, HK1 antibody, glycolytic enzyme antibody, hexokinase type I antibody, HK I antibody, brain form hexokinase antibody, hexokinase-1 antibody, hexokinase 1 antibody|
|Cellular Localization||Mitochondrion outer membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human HXK I. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (92%), Zebrafish (84%), Xenopus laevis (86%), Pig (93%), Chicken (88%), Bovine (93%)|